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GnRH-agonists : Subcutaneous muscular injection (daily, monthly, in 3-6 month intervals) Proposed mechanisms include: Stimulate the release of LH and FSH from the pituitary gland in the first 10 days

A functional medicine strategy focuses on identifying and removing immune triggers, supporting immune regulation, restoring tolerance, and addressing underlying drivers such as gut dysfunction, chronic infections, toxin exposure, and nervous system dysregulationrather than relying solely on immune suppression

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Lappas M, Rice GE

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In vitro, isolated PSCs in the high-glucose group expressed higher levels of -SMA and collagen I and had a higher cell proliferation rate